Mezlocillinの嫌気性菌に対する抗菌作用

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  • ANTIBACTERIAL ACTIVITY OF MEZLOCILLIN AGAINST ANAEROBIC BACTERIA
  • Mezlocillin ノ ケンキセイキン ニ タイスル コウキン サヨウ

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Antibacterial activity of Mezlocillin against anaerobic bacteria was tested in comparison with that of Ampicillin (ABPC), Carbenicillin (CBPC), Cefazolin (CEZ) and Clindamycin (CLDM).<BR>MIC of Mezlocillin against Genus Fusobacterium was inferior to ABPC, CBPC, CEZ and CLDM.<BR>Mezlocillin showed low level of MIC against Bacteroides, Gram positive bacilli and cocci similarly to ABPC and CLDM, and its antibacterial activity was superior to CBPC and CEZ.<BR>Natural resistant mutants of Ps. anaerobius and F. varium were not obtained on GAM agar plates containing 1000 μg/ml to 62.5 μg/ml of Mezlocillin.<BR>Subcutaneous abscess treatment of experimental mice infections due to F. necrophorum with Mezlocillin proved to be effective when the causative organisms were sensitive in vitro against this drug.

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