BASIC AND CLINICAL STUDIES OF MEZLOCILLIN IN THE FIELD OF SURGERY

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  • ISHII TETSUYA
    First Department of Surgery, Hiroshima University, School of Medicine
  • YOKOYAMA TAKASHI
    First Department of Surgery, Hiroshima University, School of Medicine
  • KISHI AKIHIRO
    First Department of Surgery, Hiroshima University, School of Medicine
  • KISHI DAIZABURO
    First Department of Surgery, Hiroshima University, School of Medicine
  • TAKEDA MASAMARU
    First Department of Surgery, Hiroshima University, School of Medicine
  • ICHIKAWA TORU
    First Department of Surgery, Hiroshima University, School of Medicine

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Other Title
  • 外科領域におけるMezlocillinの基礎的ならびに臨床的検討
  • ゲカ リョウイキ ニ オケル Mezlocillin ノ キソテキ ナラビニ

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Abstract

Fundamental and clinical investigations on mezlocillin, a new penicillin antibiotic, was carried out.<BR>1. Antibacterial activity of mezlocillin was tested against various organisms isolated clinically in surgical field. Mezlocillin showed slightly better sensitivity against E. coli and Enterobacter than carbenicillin and it showed the same sensitivity against other organisms isolated.<BR>2. The average serum level was about 30μg/ml after intravenous injection of 1 g, about 14μg/ml at 1 hour.<BR>The average excretion into urine was about 48%(40-58%) in 6 hours.<BR>Mezlocillin attained the peak bile level of 1, 070μg/ml at 2 hours after drip infusion of 2g.<BR>3. Mezlocillin was administered to 9 cases, and clinical response was excellent in 1 case, good in 5 cases, moderate in 1 case and poor in 1 case, with effectiveness of 75%.<BR>No side effects due to the drug was seen in any case.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 27 (Supplement1), 352-356, 1979

    Japanese Society of Chemotherapy

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