産婦人科領域におけるMezlocillinの基礎的, 臨床的研究

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  • LABORATORY AND CLINICAL STUDIES ON MEZLOCILLIN IN THE FIELD OF GYNECOLOGY AND OBSTETRICS
  • サンフジンカ リョウイキ ニ オケル Mezlocillin ノ キソテキ リ

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Laboratory and clinical studies of mezlocillin in gynecology and obstetrics showed the following results:<BR>1. Antibacterial activity:<BR>Minimal inhibitory concentration of mezlocillin against 115 strains recently isolated from patients ranged mostly from 0.39 to 25μg/ml in Staphylococcus epidermidis and Strept. faecalis, 1.56 to 3.13μg/ml and 25 to 100μg/ml in Escherichia coli, 3.13 to 12.5μg/ml in Proteus mirabilis, 0.78 to 400μg/ml in Citrobactei freundii and Serratia marcescens.<BR>2. Concentration of mezlocillin in maternal serum, umbilical cord serum and amniotic fluid: 40 minutes after administration of 1 g of mezlocillin i. v. levels in maternal and umbilical cord serum were 38μg/ml and 15μg/ml respectively.<BR>In umbilical cord blood concentration was about 1/3-3/4 times as high as in mothers blood.<BR>The Eeak level obtained in aminiotic fluid was 8.0 to 8.1μg/ml at 3 to 3.3 hours after administration, and then excretion pattern was gradually observed.<BR>3. Clinical results:<BR>Mezlocillin was applied clinically in 21 cases (intrauterine infection in 4 cases, pelvic infection in 4 cases, sepsis in 2 cases and urinary tract infection in 11 cases) and results obtained were excellent in 11 cases (52.4%), good in 8 cases (38.1%) and poor in 2 cases (9.5%). The results classified as excellent were obtained almost exclusively in urinary tract infections.<BR>4. Side effects:<BR>No side effects were observed.

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