Ticarcillin (TIPC) の基礎的・臨床的検討

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  • BASIC AND CLINICAL STUDIES ON TICARCILLIN
  • Ticarcillin TIPC ノ キソテキ リンショウテキ ケントウ

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A new antibiotic, ticarcillin (TIPC) was studied on its antibacterial activity and clinical effects, and the following results were obtained.<BR>1) Sensitivity of microorganisms to TIPC which were isolated from sputa of patients with chronic respiratory diseases was tested by agar plate dilution method, and compared with that of aminobenzylpenicillin (ABPC) and sulfobenzylpenicillin (SBPC).<BR>The minimum inhibitory concentrations of TIPC against 47 strains of H. influenzae, 25 strains of Klebsiella, 26 strains of E. coli, 16 strains of Enterobacter and 50 strains of Ps. aeruginosa were 0.2 or less to 25 μg/ml, 50 to 200 μg/ml or over, 1.56 to 100 μg/ml or over, 1.56 to 100 μg/ml or over, 0.39 or less to 800μ g/ml or over respectively. The antibacterial activity of TIPC was the same to that of ABPC, SBPC against H. influenzae and superior to that of SBPC against Ps. aeruginosa.<BR>2) In 8 cases of Ps. aeruginosa infections, bacteriological elimination was obtained in 3 cases of chronic bronchiolitis, and clinical improvements of symptoms were observed in 7 cases.<BR>3) No side effects were found.

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