Ticarcillinにかんする研究

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タイトル別名
  • STUDIES ON TICARCILLIN
  • Ticarcillin ニ カンスル ケンキュウ

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Ticarcillin, a new broad spectrum penicillin preparation, has been investigated to give following results.<BR>1. To measure the M. I. C.s of ticarcillin against 215 strains of Pseudomonas aeruginosa isolated from patients, using plate dilution method, 173 strains of those organisms were in the range 25 to 100 μg/ml. Antimicrobial activity of ticarcillin against Pseudomonas aeruginosa was higher than that of carbenicillin.<BR>2. The mean peak blood level in 4 female patients was 153. 8 μg/ml in 15 minutes following administration of 2 g intravenously. The mean of half life in the blood was found to be 1. 44 hours and the urinary recovery rate was 57. 5% in 6 hours.<BR>3. Thirty one patients with various infections were treated with ticarcillin receiving 2 to 6 g per day intravenously. Five of 31 patients were excellent (cured) and 18 were good. Four patients with chronic infections were poor response. As to the side effect of the drug, rash and pain at chest, belly and back in injection was occurred in one patient and eosinophilia and pyrexia in other patient.

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