産婦人科領域におけるbiapenemの基礎的及び臨床的検討

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  • Pharmacokinetic and clinical studies on biapenem in the field of obstetrics and gynecology

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The pharmacokinetic and Clinical studies of biapenem (BIPM), a new 4-methyl carbapenem antibiotic possessing a stability for human renal dehydropeptidase-I were carried out.<BR>1. The concentrations of BIPM in serum, internal genital organs and retroperitoneal fluid after intravenous drip infusion of 300mg dose were examined. The peripheral serum level was 13.6μg/ml at 0 min, decreased to 0.4μg/ml at 6 hr after administration. The genital tissue's concentrations were 2.2-3.9μg/g at 75 min, and detected 0.2μg/g in all tissues without Endmetrium until 250 min after administration. The concentrations in retroperitoneal fluid were 7.8μg/ml at 30 min (peak level), decreased to 0.7μg/ml at 6 hr after administration.<BR>2. In a clinical trial, BIPM was administered to 6 patients. Clinical response was excellent in 3 cases and good in 3 cases. Principal causative organisms were Staphylococcus. aureus, Staphylococcus. epidermidis and the bacteriological response was evaluated as eradicated in 2 strain. No side effects or abnormal laboratory findings due to BIPM were observed.

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