デヒドロペプチダーゼ-I (DHP-I) の組織内分布の種差とpanipenemの代謝に及ぼす影響
書誌事項
- タイトル別名
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- <I>IN VITRO</I> DEHYDROPEPTIDASE-I ACTIVITY AND ITS HYDROLYTIC ACTIVITY OF PANIPENEM IN SEVERAL TISSUES IN ANIMAL SPECIES AND THEIR INFLUENCE ON THE DISPOSITION OF PANIPENEM <I>IN VIVO</I>
抄録
The influence of dehydropeptidase-I (DHP-I) activity on the elimination of panipenem (PAPM) in vivo was studied by examining glycyldehydrophenylalanine (GDPA) and PAPM hydrolytic activities in several tissues in animal species.<BR>Renal GDPA hydrolytic activity was the highest in mice followed with rabbits, dogs, monkeys and humans, while in rats, it was the highest in the lung.<BR>Tissues with high DHP-I activities have mostly high PAPM hydrolytic activity, which suggests DHP-I is strongly associated with the hydrolytic metabolism of PAPM. On the other hand, since the high DHP-I activity of human kidney has rather low PAPM hydrolytic activity, there exist species differences in substrate specificity of the DHP-I.<BR>In rats, the plasma elimination of PAPM was the fastest accompanying with high plasma concentration of the hydrolytic product among animal species tested.<BR>These results indicate the metabolic disposition of PAPM is deeply dependent on DHP-I activity especially in the lung and the kidney.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 39 (Supplement3), 236-241, 1991
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681261719936
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- NII論文ID
- 130004197449
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- ISSN
- 18845894
- 00093165
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可