Development of a dosage guideline based on vancomycin pharmacokinetics in neonates and infants
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- Imano Hideki
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Ueno Kazuyuki
- Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
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- Ikura Megumi
- Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
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- Yoshimura Hironori
- Department of Pharmacy and Department of Pharmacy and Clinical Laboratory Medicine, National Cardiovascular Center
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- Mitsutake Kotaro
- National Cardiovascular Center
Bibliographic Information
- Other Title
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- 新生児および乳児におけるvancomycin体内動態にもとづく投与指針の構築
Abstract
To establish a dosage guideline for vancomycin (VCM) in hospitalized infants and neonates, we studied pharmacokinetic parameters. Subjects were 5 neonates and 16 infants undergoing vancomycin therapy to treat infections by MRSA during between August 1998 and August 2001 at our hospital. Pharmacokinetic parameters of vancomycin were estimated by the Sawchuk-Zaske method. A good correlation was obtained between VCM clearance (CL) and body weight (BW). Although good correlations were obtained between serum creatinine (Scr) and the CL and between Scr and elimination half-life, no good correlations were obtained between Vd and Scr and between Vd and BW. Vd in infants and neonates was significantly less than that in adults (0.499±0.199 versus 0.717±0.0249L/h/kg, P<0.05). These results suggested that BW and Scr are useful parameters for developing a dosage guideline.
Journal
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- Japanese Journal of Chemotherapy
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Japanese Journal of Chemotherapy 51 (2), 87-90, 2003
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390282681262258048
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- NII Article ID
- 130004298156
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- ISSN
- 18845886
- 13407007
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed