Clinical study of penetration of flomoxef into serum and pancreatic juice.

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  • Ｆｌｏｍｏｘｅｆのすい液移行に関する臨床的検討

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To evaluate the organ penetration of flomoxef (FMOX), we investigated its concentration in serum and pancreatic juice of 14 patients after intravenous injection of a 2 g FMOX. The results obtained were as follows:<BR>1. The peak concentration of FMOX in serum was 134.3±32.1 μg/ml and occured 30 minutes after administration.<BR>2. The peak concentration of FMOX in pancreatic juice was 4.69±4.12 μg/ml and occured 30 minutes after administration.<BR>3. High concentrations of FMOX in pancreatic juice were observed even at 2 hours after administration.<BR>4. Bacteria isorated from drained pancreatic juice were mainly Escherichia coli and Klebsiella pneumoniae for which the MIC of FMOX was less than 0.1 μg/ml. Thus FMOX was affective against these bacteria in pancreatic juice.<BR>5. Rates of penetration of FMOX into pancreata affected by fibrosis were lower than into pan-creata without fibrosis.

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Details 詳細情報について

  • CRID
    1390282681262522496
  • NII Article ID
    130004297833
  • DOI
    10.11250/chemotherapy1995.45.741
  • ISSN
    18845886
    13407007
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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