Fundamental and clinical study of cefozopran

DOI
  • Nozue Norio
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Ono Yasuo
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Guji Atsuko
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Ohyatsu Isao
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Aoki Masumi
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Nishiya Hajime
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Miyashita Taku
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Haga Toshiaki
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine
  • Miyashita Hideo
    Department of Internal Medicine, Division 2, Teikyou University, School of Medicine

Bibliographic Information

Other Title
  • Cefozopranに関する基礎的, 臨床的検討

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Description

Cefozopran, a newly developed injectable cephalosporin, was studied fundamentally and clinically. As a result of sensitivity test of clinical isolates to this drug, the drug showed excellent antimicrobial activity against gram-negative bacilli such as Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli, which was almost equivalent to that of ceftazidime and imipenem. This drug was administered to 3 patients with pneumonia and, one patient with pulmonary emphysema associated with infection. The drug was markedly effective in 3 and slightly effective in 1. Slight elevations of GOT and GPT were observed in one patient, but their relation to this drug was unknown.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 41 (Supplement4), 176-179, 1993

    Japanese Society of Chemotherapy

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