抗菌薬の免疫グロブリン産生およびリンパ球増殖におよぼす影響

DOI

書誌事項

タイトル別名
  • Influence of various antibiotics on B cell immunoglobulin secretion and lymphocyte growth.

抄録

The influence of 7 antibiotics on immunoglobulin (Ig) secretion by human B cells and lymphocyte growth was investigated in vitro. Highly purified human peripheral B cells were cultured with anti-CD 3 activated mitomycin C-treated T cells in the presence or absence of antibiotics. Ig content in supernatants was analyzed by specific sandwich ELISA and cellular growth by a rapid colorimetric method. Erythromycin, clarithromycin, fosfomycin, tobramycin, and amikacin had no apparent effect on IgG secretion. Grepafloxacin did not affect IgG secretion at 1μg/mL or lower concentrations, whereas IgG secretion in the presence of 5μg/mL or higher concentrations was inhibited significantly. Compared to grepafloxacin, ofloxacin did not influence IgG secretion and failed to induce suppression at a concentration of 1 or 5μg/mL. Antibiotics other than grepafloxacin did not affect cellular growth. Grepafloxacin, however, significantly inhibited cellular growth at a concentration of 5gg/mL. These observations suggest that among the 7 antibiotics we studied, only grepafloxacin may modify humoral immune defense. Note that grepafloxacin induced immunomodulation at clinically attainable concentrations.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681263058816
  • NII論文ID
    130004298001
  • DOI
    10.11250/chemotherapy1995.48.898
  • ISSN
    18845886
    13407007
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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