Basic and clinical studies on cefozopran in the surgical field
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- Yura Jiro
- First Department of Surgery, Nagoya City University Medical School
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- Shinagawa Nagao
- First Department of Surgery, Nagoya City University Medical School
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- Ishikawa Shu
- First Department of Surgery, Nagoya City University Medical School
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- Mizuno Akira
- First Department of Surgery, Nagoya City University Medical School
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- Mashita Keiji
- First Department of Surgery, Nagoya City University Medical School
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- Ishikawa Masakazu
- First Department of Surgery, Nagoya City University Medical School
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- Ishihara Hiroshi
- First Department of Surgery, Nagoya City University Medical School
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- Suzuki Tatsuya
- Department of Surgery, Takahama City Hospital
Bibliographic Information
- Other Title
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- 外科領域におけるcefozopranの基礎的・臨床的検討
Abstract
We performed basic and clinical studies on cefozopran, a newly developed injectable cephem antibiotic, in the field of surgery. The following results were obtained.<BR>1) Antibacterial activity: The MIC50/MIC90 (μg/ml) values of cefozopran against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were 50/100, 0.1/0.2, 0.2/3.13 and 6.25/25, respectively.<BR>2) Delivery into bile: Concentrations of cefozopran in bile were measured in two postoperative patients after intravenous injection of 1g. The peak level in bile were 24.6μg/ml and 26.0μg/ml, respectively.<BR>3) Clinical evaluation: 28 patients with surgical infections were treated with cefozopran. Clinical efficacy was excellent in 10, good in 10, fair in 6 and poor in 2, the overall efficacy rate being 71.4%. The bacteriological response was “eradicated” in 10, “replaced” in 2, “partially eradicated” in 5 and “persisted” in 4, resulting in a 57.1% eradication rate. No adverse reactions were observed, and mild abnormal changes in laboratory findings appeared in five patients.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 41 (Supplement4), 341-348, 1993
Japanese Society of Chemotherapy
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Keywords
Details 詳細情報について
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- CRID
- 1390282681263680128
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- NII Article ID
- 130004198322
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- ISSN
- 18845894
- 00093165
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed