Basic and clinical studies on cefozopran in the surgical field

DOI
  • Yura Jiro
    First Department of Surgery, Nagoya City University Medical School
  • Shinagawa Nagao
    First Department of Surgery, Nagoya City University Medical School
  • Ishikawa Shu
    First Department of Surgery, Nagoya City University Medical School
  • Mizuno Akira
    First Department of Surgery, Nagoya City University Medical School
  • Mashita Keiji
    First Department of Surgery, Nagoya City University Medical School
  • Ishikawa Masakazu
    First Department of Surgery, Nagoya City University Medical School
  • Ishihara Hiroshi
    First Department of Surgery, Nagoya City University Medical School
  • Suzuki Tatsuya
    Department of Surgery, Takahama City Hospital

Bibliographic Information

Other Title
  • 外科領域におけるcefozopranの基礎的・臨床的検討

Abstract

We performed basic and clinical studies on cefozopran, a newly developed injectable cephem antibiotic, in the field of surgery. The following results were obtained.<BR>1) Antibacterial activity: The MIC50/MIC90 (μg/ml) values of cefozopran against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were 50/100, 0.1/0.2, 0.2/3.13 and 6.25/25, respectively.<BR>2) Delivery into bile: Concentrations of cefozopran in bile were measured in two postoperative patients after intravenous injection of 1g. The peak level in bile were 24.6μg/ml and 26.0μg/ml, respectively.<BR>3) Clinical evaluation: 28 patients with surgical infections were treated with cefozopran. Clinical efficacy was excellent in 10, good in 10, fair in 6 and poor in 2, the overall efficacy rate being 71.4%. The bacteriological response was “eradicated” in 10, “replaced” in 2, “partially eradicated” in 5 and “persisted” in 4, resulting in a 57.1% eradication rate. No adverse reactions were observed, and mild abnormal changes in laboratory findings appeared in five patients.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 41 (Supplement4), 341-348, 1993

    Japanese Society of Chemotherapy

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