書誌事項
- タイトル別名
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- Antibacterial activity of an oral quinolone, balofloxacin, and its clinical effects on respiratory infectious diseases
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The in vitro antibacterial activity of a newly developed oral quinolone, balofloxacin (BLFX), and its clinical effects on respiratory infectious diseases were investigated. The antibacterial activity of BLFX against 236 strains of 8 species of clinical isolates tended to be greater for gram-positive bacteria and less for gram-negative bacteria than existing quinolone preparations. When BLFX was orally administered at a dose of 100mg or 200mg twice a day for 6-14 days to 15 patients with respiratory infectious diseases, the clinical efficacy was excellent in 2 and good in 13, for an efficacy rate of 100%. Four strains of gram-positive cocci and 8 strains of gram-negative bacteria were isolated from 10 patients as the causative organisms, and all 12 strains were eradicated. No abnormal changes in clinical laboratory test values and no side effects were observed in any of the patients.<BR>Although BLFX exhibited no marked in vitro antibacterial activity, it exerted clinical efficacy equivalent to existing quinolone. It had no problem with safety. These results suggest that BLFX is useful for the treatment of respiratory infectious diseases.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 43 (Supplement5), 174-179, 1995
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681265264512
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- NII論文ID
- 10005468552
- 130004297434
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可