Synthesis and the solid-state conformations of cross-linked resin-bound oligo(leucine)s. Internal aggregations through the intermolecular hydrogen bonding of the oligopeptides on the polymer networks.

DOI 15 Citations 26 References Open Access
  • Narita Mitsuaki
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology
  • Isokawa Shizuko
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology
  • Tomotake Yasuko
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology
  • Nagasawa Satoshi
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology

Bibliographic Information

Other Title
  • Synthesis and the Solid-State Conformations of Cross-Linked Resin-Bound Oligo(leucine)s.1,2 Internal Aggregations through the Intermolecular Hydrogen Bonding of the Oligopeptides on the Polymer Networks

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Description

Cross-linked and soluble polystyrene resin-bound oligo(leucine)s were prepared by the step-by-step coupling of Boc-Leu3-OH to H-Phe-resins using dicyclohexylcarbodiimide and 1-hydroxy-1H-benzotriazole. The solid state conformational analysis of H(\\llap–Leu3) \\llap–nPhe-resins (n=1—5), cross-linked resin; n=1—3, soluble resin) by infrared spectroscopy indicated that the pep-tide chains had various conformations depending on the chain length: n=1, essentially an unordered conformation; n=2—4, mainly the β-structure; and n=5, predominantly the α-helix. The formation of the β-structure indicates that resin-bound peptide chains can easily interact with each other through hydrogen bonds even in polymer networks. The correlation of the conformation in the swollen state with that in the solid state was examined using various solvents. Effects of shear stress on conformational transformations of H(\\llap–Leu3) \\llap–nPhe-resins (n=1—3) was also examined.

Journal

  • Polymer Journal

    Polymer Journal 15 (1), 25-32, 1983

    The Society of Polymer Science, Japan

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Details 詳細情報について

  • CRID
    1390282681265557632
  • NII Article ID
    130004428445
  • DOI
    10.1295/polymj.15.25
  • COI
    1:CAS:528:DyaL3sXktVKjs70%3D
  • ISSN
    13490540
    00323896
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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