Micafunginの高齢者における薬物動態

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  • Pharmacokinetic study of micafungin in elderly subjects

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The pharmacokinetics of micafungin (MCFG) were studied in 10 elderly volunteers (aged 66-78 years) and 10 non-elderly volunteers (aged 20-24 years) all of whom were healthy males. MCFG was given intravenously at a single administration of 50 mg with continuous infusion pump over a 1-hour period. The plasma concentrations of unchanged drug declined in a bi-exponential way both in elderly and non-elderly subjects after cessation of infusion. In the elderly and non-elderly, respectively, these values were found: maximum plasma concentration (Cmax) of unchanged drug, 4.97±0.60 (mean±S.D.) and 4.95±0.56, ug/mL; elimination half-life (t1/2), 14.9±1.0 and 15.2±0.9 h; volume of distribution at steady state (Vdss), 0.239±0.027 and 0.228±0.016 L/kg; total clearance (CLt), 12.0±1.7 and 11.1±1.2 mL/h/kg; plasma protein binding rate, 99.85±0.01 and 99.85±0.02%. Since there were no significant differences in pharmacokinetic parameters or the plasma protein binding rate, it was concluded that the pharmacokinetics of MCFG were similar in both elderly and non-elderly subjects.

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