書誌事項
- タイトル別名
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- Pharmacokinetic study of micafungin in elderly subjects
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抄録
The pharmacokinetics of micafungin (MCFG) were studied in 10 elderly volunteers (aged 66-78 years) and 10 non-elderly volunteers (aged 20-24 years) all of whom were healthy males. MCFG was given intravenously at a single administration of 50 mg with continuous infusion pump over a 1-hour period. The plasma concentrations of unchanged drug declined in a bi-exponential way both in elderly and non-elderly subjects after cessation of infusion. In the elderly and non-elderly, respectively, these values were found: maximum plasma concentration (Cmax) of unchanged drug, 4.97±0.60 (mean±S.D.) and 4.95±0.56, ug/mL; elimination half-life (t1/2), 14.9±1.0 and 15.2±0.9 h; volume of distribution at steady state (Vdss), 0.239±0.027 and 0.228±0.016 L/kg; total clearance (CLt), 12.0±1.7 and 11.1±1.2 mL/h/kg; plasma protein binding rate, 99.85±0.01 and 99.85±0.02%. Since there were no significant differences in pharmacokinetic parameters or the plasma protein binding rate, it was concluded that the pharmacokinetics of MCFG were similar in both elderly and non-elderly subjects.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 50 (Supplement1), 148-154, 2002
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681266404736
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- NII論文ID
- 10010203688
- 130004102627
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可