Pharmacokinetic and clinical studies of gatifloxacin on otorhinolaryngological infections
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- Baba Shunkichi
- Department of Otorhinolaryngology, Nagoya City University, Medical School
Bibliographic Information
- Other Title
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- 耳鼻咽喉科領域感染症に対するgatifloxacinの基礎的・臨床的検討
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Abstract
Pharmacokinetic and clinical studies were carried out with gatifloxacin (GFLX) in otorhinolaryngological infections.The results were as follows:<BR>1. The concentration of GFLX in the mucous membrane of the middle ear was 2.68-3.64μEg/g, in the mucous membrane of paranasal sinuses was 0.30-2.49μEg/g, and in the tonsils, 0.06-3.12μg/g.<BR>2. Clinical efficacy rates were 77.8%(28/36) in otitis media, 96.4%(27/28) in paranasal sinusitis, and 81.8%(18/22) in tonsillitis.Overall clinical efficacy was assessed as excellent in 48 cases, good in 33, fair in 10 and poor in 5, the efficacy rate being 84.4%(81/96).<BR>Bacteriological elimination rates were 85.7%(60/70) for Gram-positive bacteria and 88.9%(24/27) for Gram-negative bacteria. The rate for anaerobes was 100%(11/11).<BR>Side effects were observed in eight of 138 cases (5.8 %), but they were slight.<BR>Abnormal laboratory findings were recorded in 2 cases (2.1 %). All were mild in degree.<BR>From the above results, we conclude that GFLX is a useful drug for the treatment of otorhinolaryngological infections.
Journal
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- Japanese Journal of Chemotherapy
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Japanese Journal of Chemotherapy 47 (Supplement2), 372-386, 1999
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390282681267531008
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- NII Article ID
- 10008029419
- 130004297968
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- NII Book ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed