Impact of Orally Administered Royal Jelly on the Dynamic Metabolism of <sup>137</sup>Cs, <sup>131</sup>I and <sup>85</sup>Sr in Mice

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  • Akada Naoki
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
  • Munekane Masayuki
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
  • Ida Takahiro
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
  • Kamino Shinichiro
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-generation Imaging Team, RIKEN Center for Life Science Technologies
  • Motomura Shinji
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-generation Imaging Team, RIKEN Center for Life Science Technologies
  • Hiromura Makoto
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-generation Imaging Team, RIKEN Center for Life Science Technologies
  • Enomoto Shuichi
    Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Next-generation Imaging Team, RIKEN Center for Life Science Technologies

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Other Title
  • 放射性セシウム，ヨウ素およびストロンチウムの代謝・排泄に対するローヤルゼリーの影響
  • ホウシャセイ セシウム,ヨウソ オヨビ ストロンチウム ノ タイシャ ・ ハイセツ ニ タイスル ローヤルゼリー ノ エイキョウ

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Abstract

The Fukushima nuclear accident released various radionuclides, including 137Cs, 131I and 90Sr, into the environment. At present, there is public concern about internal exposure to these radionuclides via contaminated foodstuffs, and therefore there is an urgent need for an effective and easily obtainable radioprotective agent. It has been reported that royal jelly (RJ) functions as an antioxidant for protection against DNA oxidation. We therefore postulated that administration of RJ would reduce internal exposure to radiation and/or promote the metabolic turnover of radionuclides. In this study, we evaluated whether or not RJ would act as a radioprotective agent. We analyzed the biodistribution of 137Cs, 131I and 85Sr in mice administered RJ orally for 1 week. Accumulation of these radionuclides was significantly decreased in the RJ-treated mice, and the radionuclides were mainly excreted into the urine. RJ decreased the accumulation of 131I in the thyroid gland particularly. In addition, we succeeded in visualizing the effect of RJ non-invasively by gamma-ray emission imaging (GREI) , which is a multiple nuclide imaging modality.

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