Studies on Preventive Effect of Casein Tryptic Hydrolysate on Cerebral Apoplexy in Rats.

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  • YAMORI Yukio
    Graduate School of Human and Environmental Studies, Kyoto University
  • NARA Yasuo
    Graduate School of Human and Environmental Studies, Kyoto University
  • IKEDA Katsumi
    Central Laboratory for Animal Models, Shimane Institute of Health Science
  • SUGAI Ryuji
    Kanebo Ltd., Biochemistry Laboratory
  • MURAKAMI Umeji
    Kanebo Ltd., Biochemistry Laboratory

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  • カゼインのトリプシン分解物のラットにおける脳卒中予防効果に関する実験的研究
  • カゼイン ノ トリプシン ブンカイブツ ノ ラット ニ オケル ノウソッチュウ

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Abstract

The preventive effect of tryptic hydrolysate of milk casein against cardiovascular disease was studied in stroke-prone spontaneously hypertensive rats (SHRSP). Blood pressure, body weight, brain weight, heart weight, survival rate, incidence of stroke and pathological data after oral administration of the hydrolysate were investigated. An amino acid mixture with the same composition as that of the hydrolysate was given to a control group. Thirty week feeding with the 10% hydrolysate significantly retarded the increase of brain weight due to cerebral edema and the incidence of stroke. In addition, the diet tended to reduce the increase of heart weight due to cardiac hypertrophy caused by hypertension. These results suggest that this tryptic hydrolysate is useful for preventing cardiovascular disease in rats and increasing their survival rate.

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