Effect of Foods on Antitumor Activity of Doxorubicin, Melphalan and Methotrexate

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  • Iwamoto Shoko
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Sunaga Katsuyoshi
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Harada Sonoko
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Ohkubo Atsuko
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Tsuda Tadashi
    Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University

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  • ドキソルビシン, メルファランおよびメトトレキサートの抗腫瘍効果に影響する食品の検討
  • ドキソルビシン,メルファラン オヨビ メトトレキサート ノ コウシュヨウ コウカ ニ エイキョウ スル ショクヒン ノ ケントウ

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Abstract

Recently, with increasing interest in the cancer-preventive effects of complementary and alternative medicine (CAMs) including functional foods and herbs, their use as health foods has been increasing among cancer patients. Although the antitumoral or cytotoxic activities of CAMs have been well examined, little is known about possible interactions between foods used as CAMs and chemotherapeutic agents. Therefore, in the present study, the effects of ethyl acetate extracts of eight foods or herbs commonly used by cancer patients on the antitumor activity of doxorubicin (DOX), melphalan (L-PAM) or methotrexate (MTX), were investigated in the hepatoma cell line HepG2. The reduction of cell number induced by L-PAM was inhibited by citrus unshiu peel, spinach or green tea extracts, and also the reduction in cell number induced by DOX was inhibited by citrus unshiu peel, broccoli or green tea extracts.

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