書誌事項
- タイトル別名
-
- Effect of Euglena(Euglena gracilis Z) with Enriched Docosahexaenoic Acid on Blood Pressure, Storoke Lesion and Life-Span in Stroke-Prone Spontaneously Hypertensive Rats.
- ノウソッチュウ イハッショウセイ コウケツアツ シゼン ハッショウ ラット ノ
この論文をさがす
抄録
From 5 weeks of age, stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet based on dry cells of Euglena (Euglena gracilis Z; at 25% in diet) with enriched docosahexaenoic acid (DHA-Euglena) until natural death or sacrifice at 20 weeks of age, and the effects of the diet on blood pressure, incidence of stroke lesions and life-span were examined. Spontaneous elevation of blood pressure was depressed by the DHA-Euglena diet after the start of feeding, and after 10 weeks of age the blood pressure remained constant at 210 to 230mmHg. The life-span of the DHA-Euglena-fed group was marked longer than that of the control group, and the incidence of cerebral stroke lesions was lower than that in the control rats. On the other hand, a defatted Euglena diet (at 20% in diet) exerted little effect on blood pressure, but obvious prolongation of life-span was observed. Suppression of aortic hypertrophy was recognized in SHRSP fed the DHA-Euglena diet, and a high level of aortic elastin was maintained. The activities of angiotensin I-converting enzyme (ACE) in the thoracic aorta and mesenteric artery were lower in the DHA-Euglena group than in the control group (p<0.05). The lipid peroxide (TBARS) level and activities of related enzymes in the blood of the DHA-Euglena group showed no difference from those in the control group. Prevention of blood pressure elevation, reduction of the incidence of cerebral stroke lesions and prolongation of life-span in SHRSP were more evident after feeding with DHA-Euglena than with ordinary Euglena. These results indicate that Euglena rich in DHA has an augmented suppressive effect against hypertensive disease in SHRSP.
収録刊行物
-
- 日本栄養・食糧学会誌
-
日本栄養・食糧学会誌 48 (3), 209-215, 1995
公益社団法人 日本栄養・食糧学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681269928064
-
- NII論文ID
- 10008562563
-
- NII書誌ID
- AN00311992
-
- COI
- 1:CAS:528:DyaK2MXmvFyksbY%3D
-
- ISSN
- 18832849
- 02873516
-
- NDL書誌ID
- 3619230
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可