Modulatory Effect of Coffee on Restrained Stress-induced Release of Neurotransmitters in Rat.

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  • Yamato Takako
    Laboratory of Food Processing, Department of Food and Nutrition, Faculty of Domestic Science, Nakamura Gakuen University
  • Kino Mayuko
    Laboratory of Nutritional Physiology, Department of Food and Nutrition, Faculty of Domestic Science, Nakamura Gakuen University
  • Obata Toshio
    Department of Pharmacology, Oita Medical University
  • Ohta Hideaki
    Laboratory of Food Processing, Department of Food and Nutrition, Faculty of Domestic Science, Nakamura Gakuen University
  • Aomine Masahiro
    Laboratory of Nutritional Physiology, Department of Food and Nutrition, Faculty of Domestic Science, Nakamura Gakuen University

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  • ラットにおける拘束ストレスに伴う神経伝達物質放出に対するコーヒーの抑制作用
  • ラット ニ オケル コウソク ストレス ニ トモナウ シンケイ デンタツ ブッシツ ホウシュツ ニ タイスル コーヒー ノ ヨクセイ サヨウ

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We investigated whether coffee and its components (caffeine and chlorogenic acid) reduce stress in rats. In vivo microdialysis was used to characterize the effects of coffee, stress, and their interaction on the serotonergic and dopaminergic systems. Immobilization of the rats for 100min markedly increased the hippocampal levels of dopamine (DA) and serotonin (5-HT). Thereafter, 100min of rest restored the levels of DA and 5-HT to basal values. Treatment with 33mg/kg instant coffee (equivalent to the amount contained in one cup of coffee) or 1.7mg/kg caffeine (equivalent to one cup of coffee) reduced the second restraint-induced increase of the neurotransmitters, especially 5-HT. On the other hand, neither saline nor 1.7mg/kg chlorogenic acid (equivalent to one cup of coffee) reduced the increases. These results suggest that coffee administration helps to relax rats subjected to restraint-induced stress, and that this effect could be due to caffeine. Taken together, these findings suggest that coffee has a modulating effect on the stress response in rats.

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