Mechanism for the Anti-tumorigenic Effects of Vitamin B<sub>6</sub>, Characterization of Neuronal Cell Injury by Homocysteine, and Relationship between Dietary Habits and Plasma Homocysteine Concentration

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  • Kanouchi Hiroaki
    Department of Veterinary Pathobiology, Joint Faculty of Veterinary Medicine, Kagoshima University

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  • ビタミンB<sub>6</sub>の抗腫瘍作用およびホモシステインの神経傷害の作用機序，食品摂取頻度と血漿ホモシステイン濃度に関する研究
  • ビタミンB₆の抗腫瘍作用およびホモシステインの神経傷害の作用機序,食品摂取頻度と血漿ホモシステイン濃度に関する研究(平成26年度日本栄養・食糧学会奨励賞受賞)
  • ビタミン B ₆ ノ コウシュヨウ サヨウ オヨビ ホモシステイン ノ シンケイ ショウガイ ノ サヨウ キジョ,ショクヒン セッシュ ヒンド ト ケッショウ ホモシステイン ノウド ニ カンスル ケンキュウ(ヘイセイ 26ネンド ニホン エイヨウ ・ ショクリョウ ガッカイ ショウレイショウ ジュショウ)
  • (Young Investigator Award of JSFNS (2014) )
  • (平成26年度日本栄養・食糧学会奨励賞受賞)

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Abstract

Vitamin B6 is reported to have anti-tumorigenic effects, but the mechanism responsible is not well understood. We found that vitamin B6 activates p53, resulting in growth suppression and apoptosis in human breast cancer MCF-7 cells. Among the vitamin B6 analogs, pyridoxal has the strongest effect. Differences in the effects of these analogs may be related to differences in cell surface interactions. Pyridoxal was observed to show the strongest binding to the cell surface among the vitamin B6 analogs. Although epidemiological studies have shown that homocysteinemia is related to dementia, precisely how homocysteine induces dementia has not been clarified. Homocysteine is an amino acid and its metabolism requires vitamin B6, folate, and vitamin B12. We conclude that U-251MG glioma cells may secrete molecules that are cytotoxic to SH-SY5Y neuroblastoma cells upon stimulation with homocysteine. Epidemiological studies on the relationship between human plasma homocysteine concentrations and dietary habits in the Amami Islands, Kagoshima Prefecture, found that a high consumption of beans or eggs was related to lower homocysteine concentrations in men and postmenopausal women respectively.

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