Effects of Dietary Water- and Fat-soluble Vitamins on Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

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  • Hanai Miho
    Department of Food Sciences, Ibaraki Christian University
  • Esashi Takatoshi
    Department of Nutritional Life Sciences, Kanagawa Institute of Technology

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  • 生活リズム撹乱モデル実験系における成長期雄ラットの生殖器官発達抑制に及ぼす飼料中水溶性ビタミンと脂溶性ビタミンの影響
  • セイカツ リズム カクラン モデル ジッケンケイ ニ オケル セイチョウキ オス ラット ノ セイショク キカン ハッタツ ヨクセイ ニ オヨボス シリョウ チュウ スイヨウセイ ビタミン ト シ ヨウセイ ビタミン ノ エイキョウ

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The purpose of this study was to clarify the effects of nutrients on the gonadal development of male rats kept under constant darkness as a model of disturbed daily rhythm. In the present study, the effects of water- and fat- soluble vitamins, and their interactions, were examined. This study was based on three-way ANOVA. The three factors were lighting conditions, water-soluble vitamins, and fat-soluble vitamins. The levels of dietary water- and fat-soluble vitamins were low, normal, or high: 1/3.3 of normal (AIN-93G diet) content, normal content, or three times the normal content, respectively. The level of protein was low, 9% casein, and other components were the same as those of the AIN-93G diet. Four-week-old Fischer 344 rats were kept under constant darkness or normal lighting (12-h light/dark cycle) for 4 weeks, and then the gonadal weights and serum testosterone concentrations were evaluated. Lighting conditions, and the interaction between lighting conditions and water- and fat- soluble vitamins, were observed to affect testis weight. Among the constant darkness groups, the highest testis weight was observed under a high water- and low fat-soluble vitamin diet, and the lowest weight was observed under a normal water- and high fat-soluble vitamin diet. On the other hand, among the normal lighting groups, the highest testis weight was observed under a normal water- and fat-soluble vitamin diet. Lighting conditions and water- and fat-soluble vitamins had no effect on serum testosterone concentration. These results suggest that the requirement of water-soluble and fat-soluble vitamins for gonadal development increases and decreases, respectively, when rats are kept under constant darkness as a model of disturbed daily rhythm, in comparison with normal lighting conditions.

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