Hypotriglyceridemic Effect of Globin Digest on Subjects with Borderline Hyperlipidemia.
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- Kagawa Kyoichi
- Pharmacological Laboratory, Hankyu Kyoei Bussan Co., Ltd.
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- Fukuhama Chizuko
- Pharmacological Laboratory, Hankyu Kyoei Bussan Co., Ltd.
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- Fujino Hiroaki
- Pharmacological Laboratory, Hankyu Kyoei Bussan Co., Ltd.
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- Okuda Hiromichi
- Second Department of Medical Biochemistry, School of Medicine, Ehime University
Bibliographic Information
- Other Title
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- 境界域高脂血症被験者におけるグロビンタンパク分解物の血清トリグリセリド低下作用
- キョウカイイキ コウシ ケツショウ ヒケンシャ ニ オケル グロビンタンパク ブンカイブツ ノ ケッセイ トリグリセリド テイカ サヨウ
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Abstract
It has already been reported that globin digest (GD) exerts a hypotriglyceridemic action in laboratory animals and humans. A tetrapeptide, Val-Val-Tyr-Pro, extracted from GD, has also been shown to be 7000-times more active than the parent GD. We studied the hypotriglyceridemic effect of GD in subjects with borderline hyperlipidemia. In normal subjects, 1g of GD showed sufficient hypotriglyceridemic action. When borderline hypertriglyceridemic subjects were administered 1g of GD as a beverage with 40g of fat, the increases in serum and chylomicron (CM) TGs at 1-5h after the administration were suppressed to 25-50% of the control values (without GD). The areas under the serum TG and CM-TG concentration curves (AUCs; 0-6h) were significantly decreased to about 40% of the control, respectively. GD enhanced the elimination rate constants of TG and CM-TG in borderline hypertriglyceridemic subjects, and showed a more effective hypotriglyceridemic action than in normal subjects. GD thus appears to be useful for prevention of cardiovascular disease and atherosclerosis in subjects with borderline hypertriglyceridemia.
Journal
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- Nippon Eiyo Shokuryo Gakkaishi
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Nippon Eiyo Shokuryo Gakkaishi 52 (2), 71-77, 1999
Japan Society of Nutrition and Food Science
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Keywords
Details 詳細情報について
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- CRID
- 1390282681270780288
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- NII Article ID
- 10009713157
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- NII Book ID
- AN00311992
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- ISSN
- 18832849
- 02873516
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- NDL BIB ID
- 4718243
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed