Effect of Sex Hormones on the Activity of Protein Kinases in Rat Ventral Prostate and Uterus

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  • ICHII SHOGO
    Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
  • IWANAGA YUKIO
    Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine
  • IKEDA AKEMI
    Division of Physiology, Institute of Steroid Research, Tottori University School of Medicine

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To elucidate the physiological role of cAMP-dependent and -independent protein kinase and cAMP-binding protein in regulation of cellular function and metabolism, activity of the protein kinases and capacity of the cAMP-binding protein were assayed in the ventral prostate and the uterus from rats of various hormonal statuses. Castration caused a significant elevation in the activity of both cAMP-dependent and -independent protein kinase and administration of testosterone to castrated rats abolished the effect of castration on the enzyme activity. In the uterus, administration of estradiol to immature rats evoked a significant decrease in the cAMP-dependent activity but not in the cAMP-independent activity of the enzyme. Deprival of the sex hormones caused an increase in the cAMP-binding capacity in both the ventral prostate and uterus. Physiological implications of these observations were discussed.

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