Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients

DOI Web Site PubMed 被引用文献8件 参考文献30件
  • Ito Yasuhiro
    Department of Surgery, Kuma Hospital, Kobe, Japan
  • Miyauchi Akira
    Department of Surgery, Kuma Hospital, Kobe, Japan
  • Ishikawa Hideki
    Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Hirokawa Mitsuhiro
    Department of Pathology, Kuma Hospital, Kobe, Japan
  • Kudo Takumi
    Department of Internal Medicine, Kuma Hospital, Kobe, Japan
  • Tomoda Chisato
    Department of Surgery, Kuma Hospital, Kobe, Japan
  • Miya Akihiro
    Department of Surgery, Kuma Hospital, Kobe, Japan

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説明

Cribriform-morular variant (CMV) is a comparably rare histological subtype of papillary thyroid carcinoma (PTC). This can be associated with familial adenomatous polyposis (FAP) due to APC gene mutations. In this study, we investigated the difference in the biological characteristics between FAP-associated and sporadic CMV. Between 1991 and 2010, 32 patients with CMV were treated in Kuma Hospital. Thirty-one of these underwent initial surgery for CMV in Kuma Hospital. Twelve patients were FAP-associated and the remaining 19 were sporadic CMV. All patients were female. Tumors of FAP-associated CMV were more frequently multiple than those of sporadic CMV. Patient age and tumor size did not differ between the two groups. Of 12 FAP-associated CMV, 5 were detected by thyroid nodule (thyroid precedent group) and 7 were detected by FAP (polyposis precedent group) as an initial manifestation. Patient age was younger and tumor size was smaller in the polyposis group than in the thyroid nodule group. All patients lacked extrathyroid extension on intraoperative finding and were node-negative on pathological examination. To date, two patients with FAP-associated CMV who initially underwent hemithyroidectomy (one in Kuma Hospital and one in another hospital) showed recurrence to the remnant thyroid during follow-up. None of the patients showed recurrence to other regions or died of carcinoma. Taken together, CMV is considered an indolent disease in our series. FAP-associated CMV showed multiple tumors more frequently than sporadic CMV. Total thyroidectomy is recommended for FAP-associated CMV, but extensive lymph node dissection is not necessary.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 58 (8), 685-689, 2011

    一般社団法人 日本内分泌学会

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