Radioimmunoassay for estimation of thyroglobulin in human serum(Note)

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  • OCHI YUKIO
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • HACHIYA TAKASHI
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • YOSHIMURA MANABU
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • MIYAZAKI TADAYOSHI
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • MAJIMA TAKAYA
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • KAIMATSU ISAO
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • TAKAHASHI HAKUO
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine

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タイトル別名
  • Radioimmunoassay for Estimation of Thyroglobulin in Human Serum
  • Radioimmunoassay for estimation of thyr

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A specific double antibody radioimmunoassay has been develop for the measurement of thyroglobulin in human serum. Human thyroglobulin was purified by combined DEAE-cellulose and affinity chromatography using Sepharose 4B-bound Concanavalin A. Sensitivity of test serum was 10 ng/ml. Thyroglobulin was not detectable in half of normal subjects, and half showed values between 10 and 180 ng/ml. In the patients with simple goiter and secondary hypothyroidism, serum thyroglobulin was usually in the normal range. In Hashimoto's thyroiditis, many sera having precipitating antibodies or high hemagglutination antibodies for thyroglobulin showed a high thyroglobulin concentration in serum probably due to a false positive reaction. In hyperthyroidism, an increased thyroglobulin level was observed in 64% of patients. However, there was no correlation between serum thyroglobulin and thyroxine levels in untreated hyperthyroidism. Serum thyroglobulin was increased significantly in some cases for several weeks after isotope therapy for the hyperthyroidism.

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