HYPERPLASIA AND METAPLASIA OF THE UTERINE EPITHELIUM FOLLOWING ESTRONE INJECTIONS IN OVARIECTOMIZED ADULT RATS GIVEN NEONATAL INJECTIONS OF SEX STEROIDS

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Female rats receiving injections of estrone for the first 20 days of postnatal life, 25μg for the first 10 days and 50μg for the next 10 days, were ovariectomized at 77-97 days of age and those given injections of testosterone propionate for 30 neonatal days, 0.5mg for the first 10 days 1.0mg for the middle 10 days and 2.0mg for the last 10 days, were ovariectomized at 161-167 days. These animals received injections of 20 or 100μg estrone for 3 weeks, from the 22nd postoperative day on. Ovariectomized adult rats given no neonatal steroid treatment also received similar estrone injections for a 3-week period. When the rats were sacrificed on the day following the last injection, increase in uterine weight was less marked in animals given neonatal injections of the sex steroid than in the controls. Following the estrone injections for 3 weeks, areas undergoing hyperplasia and squamous metaplasia were found in the uterine epithelium in all the rats receiving neonatal steroid injections, the changes being most marked in the cervical region. The control rats exhibited no such changes in the uterine epithelim.

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