NEUROSECRETION OF OXYTOCIN STIMULATES THE RELEASE OF THE PITUITARY GONADOTROPHIN

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1) Young male albino rats, mongrel dogs, and human subjects were employed to examine the effect of exogenous injection of oxytocin on the pituitary-gonadal system.<BR>2) By the injection of oxytocin, the pituitary-gonadal system is strongly stimulated, and the secretion of pituitary gonadotrophin markedly increases judged by the urinary output of pituitary gonadotrophin, the chromatographic fractionations of urinary 17-ketosteroids, and by the histological findings of the adenohypophysis and the gonads.<BR>3) Brief discussions are made on the role played by the hypothalamic pituitary neurosecretion with regard to the stimulation of the anterior pituitary in the natural stress response.

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