Studies on the changes of serum FSH, LH and prolactin concentrations in pubertal twins.

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  • WASADA T.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • AKAMINE Y.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • OMA H.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • NAWATA H.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • MOTOMATSU T.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • KATO K.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • IBAYASHI H.
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University

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タイトル別名
  • Studies on the Changes of Serum FSH LH

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The cross-sectional study was undertaken to investigate the correlation of serum gonadotropin levels with physical signs of puberty and also to assess the role of genetic factors in the onset and progression of puberty. Serum concentrations of FSH, LH and prolactin were measured by double antibody radioimmunoassay in 195 monozygotic and 59 dizygotic twin pairs during the years of puberty (12 to 15 years). In boys, serum FSH, LH and prolactin concentrations showed a tendency to increase steadily alone with bone ages (9 to 17 years). The size of testis correlated fairly well with serum LH levels and to some extent with FSH. In the pubic hair stage, a significant difference was observed in serum FSH and LH levels between the groups of PH 1-2 and PH 3<. In girls, serum FSH levels significantly increased in the early phase of puberty and no further increase occurred thereafter, while serum LH and prolactin levels showed an increasing trend with the advance of bone ages to adult levels. As to breast development, serum LH levels alone increased during the early stages of development. When a comparison was made between pre-and postmenarchial groups or between pubic hair stages, a significant difference was present only in LH levels in either comparison.<BR>From a viewpoint of twin zygosity, the intrapair differences of serum gonadotropin levels were compared between monozygotic and dizygotic pairs of twins. Serum LH levels in both sexes and serum FSH in girls of monozygotic pairs of twins showed a significant within-pair similarity compared with dizygotic pairs of twins. Since serum LH levels appeared to have a close relationship with the advancement of puberty in both sexes, these findings suggest that genetic factors play an important role in the onset and progression of individual puberty.

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