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Fetal rat adrenal steroidogenesis and steroid transfer to adrenalectomized mother.
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- MILKOVIC STEVAN
- Laboratory for Experimental Medicine, University of Zagreb
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- KLEPAC RATIMIR
- Institute of Biology, School of Medicine, University of Zagreb
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- MILKOVIC KARMELA
- Institute of Biology, School of Medicine, University of Zagreb
Bibliographic Information
- Other Title
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- Fetal rat adrenal steroidogenesis and steroid transfer to adrenalectomized mother(Note)
- Fetal rat adrenal steroidogenesis and s
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Description
On the 22nd day of gestation in rats, fetuses of acutely adrenalectomized mothers were injected subcutaneously with 0.43μCi 4-14C-progesterone in 0.05 ml saline. Ten and 20min after injection to fetuses, samples were taken to determine the 14C progesterone metabolites in the plasma and adrenal glands.<BR>After extraction of the samples taken, the metabolites were separated by twodimensional thin-layer chromatography and identified by autoradiography. 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone, corticosterone and 11β-hydroxyprogesterone were identified in the plasma of injected fetuses, and, in far smaller amounts, in the plasma of their mothers. The plasma of noninjected fetuses also contained very small amounts of these corticoids. The fetal adrenal glands contained far smaller amounts of radioactive steroids than the fetal plasma did.<BR>The results obtained show that steroids of fetal origin can cross the placenta in and out, constituting evidence that the fetal adrenal glands are the only source of the plasma corticoids of their adrenalectomized mothers.
Journal
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- Endocrinologia Japonica
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Endocrinologia Japonica 23 (6), 527-530, 1976
The Japan Endocrine Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282681275986432
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- NII Article ID
- 130000955905
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- NII Book ID
- AA00635052
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- ISSN
- 21856370
- 00137219
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- NDL BIB ID
- 1799121
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- PubMed
- 1022526
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed