Effect of acute exercise on insulin binding to erythrocytes in type II diabetes.

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  • IWASAKI MAKOTO
    The Third Department of Medicine, Shiga University of Medical Science
  • KOBAYASHI MASASHI
    The Third Department of Medicine, Shiga University of Medical Science
  • OHGAKU SEIJI
    The Third Department of Medicine, Shiga University of Medical Science
  • MAEGAWA HIROSHI
    The Third Department of Medicine, Shiga University of Medical Science
  • SHIGETA YUKIO
    The Third Department of Medicine, Shiga University of Medical Science

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  • Effect of Acute Exercise on Insulin Binding to Erythrocytes in type 2 Diabetes
  • Effect of Acute Exercise on Insulin Bin

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We studied the effect of acute short-term exercise on insulin binding to erythrocytes in patients with non-insulin dependent diabetes mellitus and normal controls. In the normal controls, insulin binding was increased immediately after the exercise and returned to the basal level at 30 min after the exercise. This increase was due to an affinity change without any change in the insulin receptor number. In contrast, insulin binding tended to decrease in the diabetics after the exercise, and this change was due to a decreased affinity without any change in the number of insulin receptors. These results indicate that the control mechanism of insulin receptor affinity in response to exercise is different in non-insulin dependent diabetics and normals.

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