<i>NUDT3</i> rs206936 is associated with body mass index in obese Japanese women

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  • Kitamoto Aya
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • Kitamoto Takuya
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • Mizusawa Seiho
    Center for Genomic Medicine, Unit of Genome Informatics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • Teranishi Hajime
    Center for Genomic Medicine, Unit of Genome Informatics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • So Rina
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
  • Matsuo Tomoaki
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
  • Nakata Yoshio
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
  • Hyogo Hideyuki
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
  • Ochi Hidenori
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
  • Nakamura Takahiro
    Laboratory for Mathematics, National Defense Medical College, Tokorozawa 359-8513, Japan
  • Kamohara Seika
    Health Science University, Yamanashi 401-0380, Japan
  • Miyatake Nobuyuki
    Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan
  • Kotani Kazuaki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
  • Komatsu Ryoya
    Rinku General Medical Center, Izumisano 598-0048, Japan
  • Itoh Naoto
    Toyonaka Municipal Hospital, Toyonaka 560-8565, Japan
  • Mineo Ikuo
    Otemae Hospital, Osaka 540-0008, Japan
  • Wada Jun
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
  • Yoneda Masato
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
  • Nakajima Atsushi
    Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
  • Funahashi Tohru
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
  • Miyazaki Shigeru
    Tokyo Postal Services Agency Hospital, Tokyo 102-8798, Japan
  • Tokunaga Katsuto
    Itami City Hospital, Itami 664-8540, Japan
  • Masuzaki Hiroaki
    Division of Endocrinology and Metabolism, Second Department of Internal Medicine, University of the Ryukyus Faculty of Medicine, Okinawa 903-0215, Japan
  • Ueno Takato
    Research Center for Innovative Cancer Therapy, Kurume University, Kurume 830-0011, Japan
  • Chayama Kazuaki
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
  • Hamaguchi Kazuyuki
    Department of Community Health and Gerontological Nursing, Faculty of Medicine, Oita University, Oita 879-5593, Japan
  • Yamada Kentaro
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University, Kurume 830-0011, Japan
  • Hanafusa Toshiaki
    Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, Japan
  • Oikawa Shinichi
    Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School, Tokyo 113-8603, Japan
  • Sakata Toshiie
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879-5593, Japan
  • Tanaka Kiyoji
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
  • Matsuzawa Yuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
  • Nakao Kazuwa
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • Sekine Akihiro
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • Hotta Kikuko
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
  • 堀田, 紀久子

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Description

The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference, waist-hip ratio measurements and visceral fat area (VFA); the latter can be accurately measured by performing computed tomography (CT). In addition to environmental factors, genetic factors play an important role in obesity and fat distribution. New genetic loci associated with body mass index (BMI) and adiposity have been identified by genome-wide association studies (GWASs). This study utilized CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to higher BMI are associated with VFA, subcutaneous fat area (SFA), and the ratio of VFA to SFA (V/S ratio). We measured the VFA and SFA of 1424 obese Japanese subjects (BMI ≥ 25 kg/m2, 635 men and 789 women) who were genotyped for 13 single nucleotide polymorphisms (SNPs) reported by recent GWASs, namely, TNNI3K rs1514175, PTBP2 rs1555543, ADCY3 rs713586, IRS1 rs2943650, POC5 rs2112347, NUDT3 rs206936, LINGO2 rs10968576, STK33 rs4929949, MTIF3 rs4771122, SPRY2 rs534870, MAP2K5 rs2241423, QPCTL rs2287019, and ZC3H4 rs3810291. The G-allele of NUDT3 rs206936 was significantly associated with increased BMI (P = 5.3 × 10-5) and SFA (P = 0.00039) in the obese Japanese women. After adjustment with BMI, the association between rs206936 and SFA was not observed. This significant association was not observed in the men. The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio. Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women.

Journal

  • Endocrine Journal

    Endocrine Journal 60 (8), 991-1000, 2013

    The Japan Endocrine Society

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