CHANGES IN THE ADRENOCORTICAL CELLS OF BULLFROGS FOLLOWING HORMONAL STIMULATION

DOI Web Site Web Site PubMed Open Access

Bibliographic Information

Other Title
  • Changes in the adrenocortical cells of bullfrogs following hormonal simulation

Search this article

Description

The effect of hormonal stimulation upon the interrenal (adrenocortical) cells of the male bullfrog (Rana catesbeiana) was investigated histologically. A single administration of 10mg of ACTH to the November frogs was followed by a rapid transformation of the lipid cells into the acidophilic summer cells, and the cortex was entirely occupied by the reserved acidophilic summer cells only within 30mins. However, within 6 hrs. the loss of lipid cells was recovered to the normal level. The adrenals of normal breeding frogs were full of particularly enlarged summer cells. When the March or April frogs received a single injection or three repeated injections of the same dose of ACTH, and even when they were unilaterally nephro-adrenalectomized, both cortical cells showed no significant change. Thus, the seasonal variation during the breeding period is too intrinsic to be modified by the addition of exogenous or endogenous ACTH. When the November frogs were administered singly with 1mg/kg metopiron, the hypertrophy of cortical cells showing the prolonged inhibition of steroidogenesis was not detectable. However, when the November frogs which had been pretreated with metopiron were injected singly with 10mg of ACTH, the effect of ACTH upon the cellular transformation was arrested. The May frogs were injected with 2 or 4 of testosterone propionate for 9 or 13days: most of the summer cells were regressed chronically, whereas the lipid cells were supplemented. From these results, it has been reinforced that the acidophilic summer cell may be originated from the lipid cell.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top