Results of Long-Term Human Growth Hormone Therapy for Pituitary Dwarfism

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  • SHIZUME KAZUO
    Department of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital Third Department of Internal Medicine, University of Tokyo Faculty of Medicine
  • MATSUZAKI FUKASHI
    Department of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital Third Department of Internal Medicine, University of Tokyo Faculty of Medicine
  • IRIE MINORU
    Department of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital Third Department of Internal Medicine, University of Tokyo Faculty of Medicine
  • OSAWA NAKAAKI
    Department of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital Third Department of Internal Medicine, University of Tokyo Faculty of Medicine

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  • Results of long-term human growth hormone theraph for pituitary dwarfism

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Abstract

Since 1961, 14 patients with pituitary dwarfism were treated with human growth hormone (HGH). In this report, the result of long term treatment for more than 2 and a half years in five patients is reported. The dose of HGH was 2-4 mg three times a week. In the first six months, a marked increase in height was observed in all cases. The increase declined gradually and in some cases HGH became almost ineffective. In such cases anti-HGH antibody was observed in the patient's blood. Bone age/height age progress ratio was less than one in most cases. No side effect was observed except pain at the site of injection. In two cases, height reached to the level above-2-D of the height of normal adult.

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