On the Hypocalcemic Effect in Rabbits of a Bovine Parotid Extract (PAROTIN)

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  • OGATA ETSURO
    The First Department of Internal Medicine, University of Tokyo
  • SUZUKI HIDERO
    The First Department of Internal Medicine, University of Tokyo
  • SHIMAZAWA EIICHIRO
    Department of Pharmacology, Research Laboratories, Teikoku Hormone Mfg. Co., Ltd.
  • NAKANOWATARI KAMEO
    Department of Pharmacology, Research Laboratories, Teikoku Hormone Mfg. Co., Ltd.
  • ASANO HIDEICHI
    Department of Pharmacology, Research Laboratories, Teikoku Hormone Mfg. Co., Ltd.

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The hypocalcemic response in rabbits to parotin (a protein fraction from the bovine parotid gland) was studied in detail. Intravenous parotin produced a significant hypocalcemia appearing at 2hr, peaking at 4hr, and returning to the control at 10hr, after the dosage. The hypocalcemia was distinct in the time course from that induced by thyrocalcitonin or adrenocorticotropin; the latter hormones produced a significant hypocalcemia within 30min. The evidence was also presented that the parotin effect was neither a consequence of the induced secretion of thyrocalcitonin or adrenocrticotropin, nor that of the suppressed secretion of parathyroid hormone. As judged from the per cent decrease, the extent of hypocalcemia was similar whether the serum calcium was assessed by the assay of total calcium or by the assay of titratable calcium. By contrast, the serum ionic calcium was apparently not influenced by the parotin administration. These results suggest that parotin acts in rabbits, largely independently of the parathyroid and calcitonin system, to cause a decline in the level of serum calcium binding capacity.

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