Effect of Starvation on Synthesis and Release of Growth Hormone and Prolactin in the Rat Anterior Pituitary

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The rates of synthesis and release of GH, prolactin, and the whole protein in the anterior pituitary were measured by an in vitro method using mature male rats. The effect of starvation for 1, 3 and 5 days on these two distinct functions of the anterior pituitary is as follows: GH synthesis (per rat and per 100g body weight) decreases progressively. GH release (per rat) does not change much, but GH release (per 100g body weight) increases. The% release of GH, therefore, increases markedly. These changes in GH synthesis and release largely explain the earlier reports on alterations in pituitary content and plasma level of GH in starved rats. Prolactin synthesis and release (per rat) do not change following starvation. However, prolactin synthesis and release (per 100 g body weight) increase. The% release of prolactin does not change. Synthesis and release of the whole pituitary protein are decreased by starvation. Calculation suggested that pituitary proteins other than GH and prolactin are also influenced by starvation.

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