Dose-dependent effect of glucose on GLP-1 secretion involves sweet taste receptor in isolated perfused rat ileum [Rapid Communication]
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- Xu Zhiwei
- Institute of Pathogen Biology and Immunology, Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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- Wang Wendong
- Institute of Pathogen Biology and Immunology, Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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- Nian Xiaofeng
- Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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- Song Guiqin
- Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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- Zhang Xiaoyun
- Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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- Xiao Hongyuan
- The First Affiliated Hospital of North University of Hebei, Zhangjiakou 075000, PR China
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- Zhu Xiaobo
- Institute of Pathogen Biology and Immunology, Department of Biochemistry, North University of Hebei, Zhangjiakou 075000, PR China
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説明
Luminal glucose is an important stimulus for glucagon-like peptide 1 (GLP-1) secretion from intestinal endocrine cells. However, the effects of luminal glucose concentration on GLP-1 secretion remain unknown. In this study, we investigated the effect of luminal glucose concentrations (3.5, 5, 10, 15, and 20 mmol/L) on GLP-1 secretion from isolated perfused rat ileum. Results showed that the perfusate glucose concentration dose-dependently stimulated GLP-1 secretion from isolated perfused rat ileum, which was eliminated by the sweet taste receptor inhibitor gurmarin (30 μg/mL), but not inhibited by phloridzin (1 mmol/L), a Na+-coupled glucose transporters inhibitor. We conclude that luminal glucose induced GLP-1 secretion from perfused rat ileum in a concentration-dependent manner. This secretion was mediated by sweet taste receptor transducing signal for GLP-1 release on the gut of rat.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 63 (12), 1141-1147, 2016
一般社団法人 日本内分泌学会