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Pathogenesis and diagnostic criteria for rickets and osteomalacia — Proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society [Opinion]

  • Fukumoto Seiji
    Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan
  • Ozono Keiichi
    Department of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
  • Michigami Toshimi
    Department of Bone and Mineral Research, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi 594-1101, Japan
  • Minagawa Masanori
    Department of Endocrinology, Chiba Children’s Hospital, Chiba 266-0007, Japan
  • Okazaki Ryo
    Third Department of Medicine, Teikyo University Chiba Medical Center, Ichihara 299-0111, Japan
  • Sugimoto Toshitsugu
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan
  • Takeuchi Yasuhiro
    Division of Endocrinology, Toranomon Hospital Endocrine Center, Tokyo 105-8470, Japan
  • Matsumoto Toshio
    Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan

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Other Title
  • Pathogenesis and diagnostic criteria for rickets and osteomalacia - proposal by an expert panel supported by ministry of health, labour and welfare, Japan, the Japanese society for bone and mineral research and the Japan endocrine society [Opinion]

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Abstract

Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completely cured or at least respond to treatment when properly diagnosed and treated according to the specific causes. On the other hand, there are no standard criteria to diagnose rickets or osteomalacia nationally and internationally. Therefore, we summarize the definition and pathogenesis of rickets and osteomalacia, and propose the diagnostic criteria and a flowchart for the differential diagnosis of various causes for these diseases. We hope that these criteria and flowchart are clinically useful for the proper diagnosis and management of patients with these diseases.

Journal

  • Endocrine Journal

    Endocrine Journal 62 (8), 665-671, 2015

    The Japan Endocrine Society

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