EFFECTS OF FLUVOXAMINE ON BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN ALZHEIMER'S DISEASE : A REPORT OF THREE CASES
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- KURITA MASATAKE
- Kotokukai Sato Hospital Department of Neuropsychiatry, Fukushima Medical University School of Medicine Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
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- SATO TADAHIRO
- Kotokukai Sato Hospital
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- NISHINO SATOSHI
- Kotokukai Sato Hospital Department of Neuropsychiatry, Fukushima Medical University School of Medicine Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
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- OHTOMO KOJI
- Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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- SHIRAKAWA HISAYOSHI
- Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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- MASHIKO HIROBUMI
- Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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- SHIN-ICHI NIWA
- Department of Neuropsychiatry, Fukushima Medical University School of Medicine
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- NAKAHATA NORIMICHI
- Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University
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OBJECTIVE : To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug.<br>CASE SUMMARY: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4.<br>DISCUSSION : Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain.<br>CONCLUSION : These cases show that fluvoxamine appears to be effective in the control of BPSD with AD.
収録刊行物
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- 福島医学会
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福島医学会 52 (2), 143-148, 2006
福島医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681281526272
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- NII論文ID
- 10026160055
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- NII書誌ID
- AA0065246X
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- COI
- 1:CAS:528:DC%2BD2sXksFOjtLo%3D
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- ISSN
- 21854610
- 00162590
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- PubMed
- 17427765
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
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- 使用不可