POSSIBLE DIFFERENTIAL DIAGNOSIS OF NEUROBLASTOMA FROM RHABDOMYOSARCOMA AND EWING'S SARCOMA BY USING A PANEL OF MONOCLONAL ANTIBODIES

DOI PubMed オープンアクセス
  • SUGIMOTO Tohru
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • SAWADA Tadashi
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • ARAKAWA Shoji
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • MATSUMURA Takafumi
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • SAKAMOTO Izumi
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • TAKEUCHI Yoshihiro
    Department of Pediatrics and Children's Research Hospital, Kyoto Prefectural University of Medicine
  • REYNOLDS C. Patrick
    U.S. Navy Tissue Bank, Naval Medical Research Institute
  • KEMSHEAD John T.
    Oncology Laboratory, Institute of Child Health
  • HELSON Lawrence
    Memorial Sloan-Kettering Cancer Center

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説明

The accurate diagnosis of malignant tumor type is essential to enable the correct therapeutic regimen to be followed and to predict a patient's prognosis. However, the differential diagnosis of “small-round-cell” tumors, represented by neuroblastoma, rhabdomyosarcoma, lymphoma/leukemia and Ewing's sarcoma, can occasionally be difficult by conventional morphological and biochemical methods. If tumor membrane markers were available, these could provide rapid and accurate diagnostic aids. In the present work, a panel of 9 monoclonal antibodies raised against hematopoietic cells (BA-1, BA-2, J-5 and B7/21), brain cells (UJ-13A, UJ-127-11 and anti-Thy-1), and neuroblastoma cells (HSAN1.2 and PI153/3) was used to analyze the membrane phenotypes of 12 neuroblastoma, 4 rhabdomyosarcoma and 3 Ewing's sarcoma cell lines and cells of 3 fresh bone marrow tumors. BA-1, UJ-127-11 and PI153/3 antibodies may be useful for the differential diagnosis of neuroblastoma from rhabdomyosarcoma and Ewing's sarcoma.

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詳細情報 詳細情報について

  • CRID
    1390282681281596032
  • NII論文ID
    130007309303
  • DOI
    10.20772/cancersci1985.76.4_301
  • ISSN
    09105050
  • PubMed
    3924704
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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