Recent studies on licorice.

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  • 甘草に関する最近の研究

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Licorice is a herb which has been extensively used as medicine in the Orient and Occident for over 2000 years. Because it tastes sweet, it is also used in various foods. In 1946, licorice was found to exert an action resembling that produced by adrenocortical hormones. Since then, the mechanism for its action has been studied. Some investigators proposed that the active ingredient glycyrrhizin inhibited steroid metabolism or bound to steroid receptors. More recently, glycyrrhetinic acid was found to inhibit 11β-hydroxy-steroid dehydrogenase. In patients with glycyrrhizin-induced pseudoaldosteronism, we recently detected a new conjugate (3-monoglucuronyl-glycyrrhetic acid) and found that this substance inhibited the above-mentioned enzyme.

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