Role of central noradrenaline and serotoninin in blood glucose regulation.

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  • 血糖調節機構における中枢ノルアドレナリンおよびセロトニンの役割

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We have studied the role of central biogenic amines in blood glucose regulation in rats. In rats, blood glucose level was 65mg/dl and serum insulin level was 45μU/ml. Streptozotosin evoked high glucose level (107mg/ml) and lowered the insulin level by 30μU/ml. Catecholamines such as adrenalin, noradrenaline enhanced the blood glucose level. On the other hand, serotonin lowered the blood glucose level. The treamtent which lowered brain noradrenaline content or increased brain serotonin content lowered the blood glucose level. These data suggest that central noradrenergic system has hyperglycemic action and serotonergic system has hypoglycemic action.

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