食道アカラシア様症候群を呈した抗セントロメア抗体陽性の１症例

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タイトル別名
  • A Case of Esophageal Achalasia-like Syndrome with Positive Anticentromere Antibodies.

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説明

We describe a 66-year-old female who demonstrated esophageal achalasia-like syndrome and posi-tive anticentromere antibodies. The patient had heartburn, vomiting after meals, and weight loss. Esophagography and esophagoscopy findings were compatible with a diagnosis of esophageal achalasia. A surgical intervention (Jekler-Lhotka method) was performed and her complaints disappeared.<br>Histological examination of the resected esophageal wall did not show diminution or absence of Auerbach's plexus, but did show atrophy of the smooth muscle layers and replacement by increased connective tissue fibers, suggesting scleroderma rather than esophageal achalasia . Therefore, autoantibodies were examined and anticentromere antibodies were found to be positive. Since this autoantibody is found characteristically in patients with the CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia) variant of systemic sclerosis, this was considered to be a rare case who is positive for anticentromere antibodies and has, so far, exhibited esophageal dysmotility as her only clinical finding, possibly because the disease is at an early stage.

収録刊行物

  • 医療

    医療 54 (10), 462-467, 2000

    一般社団法人 国立医療学会

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