PZAによる過尿酸血症と主たる副作用についての検討

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タイトル別名
  • Studies on Hyperuricemia and Side Effects Produced by PZA
  • PZA ニ ヨル カニョウサン ケツショウ ト シュタル フクサヨウ ニ ツイテ ノ ケントウ

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During the period from August 1964 until April 1967 seventy two cases of inpatients were subjected in this investigation of hyperuricemia and chief side effects due to PZA in the treatment of pulmonary tuberculosis.<br>The results obtained were as follows:<br>By the colorimetric measurement it was confirmed that after 'administration of PZA serum uric acid level in all of the cases rose up to 6-20mg% and continued during the course of PZA treatment, on the other hand by cessation of PZA it returned to normal value (i.e. 1.8-5.9mg/%) without exception.<br>On the basis of the results of measurements in which individual tendency in the grade of hyperuricemia during PZA therapy were noticed, we tried to divide all cases into 3 groups and investigate each characteristics.<br>In our observation, however, any close relationship was not found between the degree of hyperuricemia and the occurrence of joint pain, but all of the cases who had complaints of joint aching were associated with hyperuricemia at the same time, therefore it should be suggested that, although hyperuricemia could be regarded as one of the causes of joint pain, another innate or acquired facotrs in the intraarticular urates precipitation as same as in gout must be taken in consideration for the incidence of joint pain.<br>Cases with joint pain due to PZA were seen totally 33 out of 72(45.8%), among them over moderate grade aching were observed in 17 patients(23.3%) and that locations were shoulder, knee, ankle elbow, wrist, finger, toe etc. But redness or swelling deformities in those joints were not found.<br>The effect of uric acid diuretics to joint pain and serum uric acid level varied individually, but almost all cases cured without cessation of PZA by probenecid or phenylbutagone.<br>We observed some cases whose joint pain due to another causes has become more severe by PZA therapy.<br>Hepatitis accompanied with jaundice produced by PZA were seen only in 4 out of 72 cases (5.5%), but there were patients with mild impairment of liver function and many cases with increase of urobilinogen in urine.

収録刊行物

  • 医療

    医療 22 (3), 294-301, 1968

    一般社団法人 国立医療学会

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