Interaction of human Waldenstrom′s IgM proteins with guinea pig and human complement

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  • IKEDA Masaharu
    Department of Biochemistry, Kyushu University School of Dentistry Department of Internal Medicine, Fukuoka University School of Medicine
  • ONOUE Kaoru
    Department of Biochemistry, Kyushu University School of Dentistry

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タイトル別名
  • Interaction of Human Waldenstrom's IgM Proteins with Guinea Pig and Human Complement
  • Interaction of human Waldenstrom s IgM
  • Interaction of Human Waldenström's IgM Proteins with Guinea Pig and Human Complement1

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説明

The activity of purified human Waldenstrom's IgM proteins to fix complement of human and guinea pig origins was compared at different temperatures using the polystyrene latex particle-adsorption method. It was shown that the interaction of the IgM proteins with complement differed depending on the source of complement and that a pronounced heterogeneity in complement-fixing activity was observed among the IgM proteins when tested with guinea pig complement. Thus, by the use of guinea pig complement, six human IgM proteins examined were classified roughly into two groups, one having a high and the other a low activity at 3 C as well as at 37 C. With human complement, five proteins showed a rather uniform activity at 37 C. However, there was one protein with no detectable activity, suggesting the presence of non-complement-fixing protein in the IgM class. All the six proteins showed no significant activity with human complement at 3 C. No antigenic difference has been found as yet in the Fc or Cμ2 region among these IgM proteins examined.

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