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- SAINO Yushi
- Tokyo Research Laboratories, Kowa Co., Ltd.
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- EDA Junji
- Tokyo Research Laboratories, Kowa Co., Ltd.
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- NAGOYA Takao
- Tokyo Research Laboratories, Kowa Co., Ltd.
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- YOSHIMURA Yoko
- Tokyo Research Laboratories, Kowa Co., Ltd.
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- YAMAGUCHI Masahito
- Tokyo Research Laboratories, Kowa Co., Ltd.
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- KOBAYASHI Fujio
- Tokyo Research Laboratories, Kowa Co., Ltd.
書誌事項
- タイトル別名
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- Chemical, Biochemical and Serological Studies and Some of Their Biological Activities
この論文をさがす
説明
Eighteen isolates of anaerobic coryneforms from human bone marrow and skin and four type strains of Propionibacterium were studied chemically, biochemically and antigenically. All of the isolates were identified as Propionibacterium acnes; of the 18 isolates, 16 belonged to serotype I and two to serotype II. By means of gas liquid chromatography and mass spectral analysis, a large amount of iso-type fatty acids, such as iso-pentadecanoic and iso-heptadecanoic acids were detected in whole cells of isolates and type strains. Antitumor and adjuvant effects of the isolates and type strains were found to differ considerably among the strains. One of the isolates, P. acnes C-7, which showed potent biological activities was fractionated by hot phenol-water extraction. The resulting insoluble middle layer was found the most effective in tumor protection, adjuvant action in immune response and phagocytic activity in mice.
収録刊行物
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- Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｉｃｒｏｂｉｏｌｏｇｙ
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Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｉｃｒｏｂｉｏｌｏｇｙ 20 (1), 17-25, 1976
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