Further Studies on the Effect of 5-Iododeoxyuridine on Polyoma Virus Multiplication in Mouse Cells
-
- KIMURA Genki
- Deparment of Bacteriology, School of Medicine
-
- MORI Ryoichi
- Deparment of Bacteriology, School of Medicine
-
- AMAKO Kazunobu
- Deparment of Bacteriology, School of Medicine
Bibliographic Information
- Other Title
-
- Further Studies on the Effect of 5‐Iododeoxyuridine on Polyoma Virus Multiplication in Mouse Cells
Search this article
Abstract
5-Iododeoxyuridine (IUDR) inhibited production of infectious polyoma virus in mouse embryo cells and mouse kidney cells in culture. Deoxythymidine reversed its effect. IUDR did not inactivate infectivity of free virus particles. IUDR did not prevent adsorption and penetration of polyoma virus to cells. The events sensitive to IUDR treatment occurred at around 20 hours after infection. The cytopathic effects of polyoma virus, including emergence of DNA containing-inclusions in the nucleus, were observable in infected cells in which viral replication was completely arrested by IUDR. It was shown by fluorescent antibody technique in infected mouse embryo cells and by complement fixation test in infected mouse kidney cells that IUDR inhibited completely the synthesis of viral antigen. No virus-like particles were demonstrated in the IUDR-treated infected-mouse kidney cells by electron microscope examinations.
Journal
-
- Japanese Journal of Microbiology
-
Japanese Journal of Microbiology 10 (4), 211-219, 1966
Center For Academic Publications Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282681295814784
-
- NII Article ID
- 130004085107
- 40018694406
-
- NII Book ID
- AA00246855
-
- COI
- 1:CAS:528:DyaF2sXktlSqsb0%3D
-
- NDL BIB ID
- 8511486
-
- ISSN
- 00215139
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed