Response of Children to Inactivated Measles Vaccine Prepared in Bovine Renal Cell Culture
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- SASAI Seijiro
- Hikari Plant, Takeda Chemical Industries, Ltd.
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- KAWANA Rinji
- Iwate Medical College
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- WAKO Hiroshi
- Kamaishi Hospital
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- IWAI Toshio
- Fuji Iron Industrial Co., Ltd
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- KANEKO Masaru
- Institute for Infectious Diseases
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- MATUMOTO Minoru
- University of Tokyo
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Abstract
Formalin-inactivated, alum-adsorbed measles vaccine was readily prepared from virus grown in calf kidney cell culture infected with the Sugiyama strain of measles virus which had been adapted to this cell culture. The vaccine induced no side reaction of any consequence in vaccinated children, but demonstrated antigenic capacity in children as well as guinea pigs, comparable to that of currently used killed measles vaccines prepared from virus grown in monkey kidney or chick embryo tissue cultures. The host system employed for the preparation of this vaccine has an advantage over monkey kidney or chick embryo tissue cultures which are currently used for manufacture of killed measles vaccine. Bovine kidneys are much easier to obtain and cultivate. Of im-portance is the fact that calf kidneys are practically free of latent virus, whereas monkey kidneys and chick embryos frequently harbor latent viruses.
Journal
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- Japanese Journal of Microbiology
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Japanese Journal of Microbiology 10 (4), 229-238, 1966
Center For Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390282681295815936
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- NII Article ID
- 40018694408
- 130004085109
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- NII Book ID
- AA00246855
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- NDL BIB ID
- 8511488
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- ISSN
- 00215139
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed