Antiinfluenzal Effect of Rugulosin

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  • NAKAMURA Shinichi
    Research and Development Division, Dainippon Pharmaceutical Co., Ltd
  • NII Fusako
    Research and Development Division, Dainippon Pharmaceutical Co., Ltd
  • INOUE Satoru
    Research and Development Division, Dainippon Pharmaceutical Co., Ltd
  • NAKANISHI Isao
    Research and Development Division, Dainippon Pharmaceutical Co., Ltd
  • SHIMIZU Masanao
    Research and Development Division, Dainippon Pharmaceutical Co., Ltd

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(-)Rugulosin showed an antiinfluenzal effect in the allantoic cavity of chicken eggs as well as in cultured chorioallantois, proving itself to be more potent than 1-adamantanamine. Also, (-)rugulo-sin, when administered by inhalation, was as effective for protection of mice against aerosol influenzal infection as orally administered 1-adamantanamine. The effect of (-)rugulosin seemed to be mainly due to direct inactivation of influenza virus.

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